#5.3.3a
the need for the removal of excretory products
To include the reasons for the deamination of amino acids and production of urea in liver cells (no details of the ornithine cycle are required).
#5.3.3b
the structure of the kidney as part of the excretory system
To include the gross structure of the kidney (cortex, medulla, renal pyramids, renal pelvis and ureter) and relative positions of the major blood vessels and organs associated with the kidney (renal artery and vein, bladder and urethra).
PAG2
#5.3.3c
(i) the structure and function of the kidney nephron related to the processes of ultrafiltration and selective re-absorption which result in the production of urine
To include the use of microscopy, diagrams and photomicrographs to examine and identify structures.
PAG1
(ii) practical investigations into the biochemical composition of ‘mock’ urine, renal artery and renal vein plasma and filtrate
PAG9
#5.3.3d
the role of the kidney in osmoregulation
To include the location and role of osmoreceptors, the secretion of ADH from the posterior pituitary, the action on ADH at the collecting ducts, the role of cyclic AMP in collecting duct cells and the insertion and removal of aquaporins into cell surface membranes.
#5.3.3e
the role of the kidney as an endocrine gland
To include an outline of the homeostatic function of erythropoietin (EPO) and renin (angiotensin).
#5.3.3f
the causes, diagnosis and consequence of kidney failure
To include causes (uncontrolled diabetes, kidney stones, blood pressure and bacterial infections), diagnosis (analysis of data from laboratory samples e.g. urine or blood composition) and consequences (renin and EPO changes and cardiovascular disease).
PAG9
#5.3.3g
the use of haemodialysis and peritoneal dialysis in the treatment of kidney failure
To include a consideration of the advantages and disadvantages of both forms.
#5.3.3h
the use of transplant surgery in the treatment of kidney failure
To include practical issues involved in the use of donor organs for kidney transplants.
#5.3.3i
the future for transplant surgery
To include the implications of therapeutic cloning and reproductive cloning and the use of stem cell technology.